Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation
deacetylation alters chromosome structure and affects transcription factor access to DNA. This protein has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene