Description
Description: HBA2 Human Recombinant produced in E Coli is a single polypeptide chain containing 179 amino acids (1-142) and having a molecular mass of 19.5 kDa.HBA2 is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction: HBA2 is a member of the globin family. HBA2 takes part in oxygen transport from the lung to the different peripheral tissues. The coding sequences of HBA2 and HBA1 are equal but have a small difference over the 5' untranslated regions and the introns, and a large difference over the 3' untranslated regions. HbA is constituted from two alpha chains and two beta chains which in standard adult life hold about 97% of the total hemoglobin; alpha chains associate with delta chains to create HbA-2 that with HbF (fetal hemoglobin) form the remaining 3% of adult hemoglobin. Alpha thalassemia is caused by removal of each of the alpha genes or removal of both HBA2 and HBA1; nondeletion alpha thalassemias has also been reported