Recombinant Human Transmembrane prolyl 4-hydroxylase MBS1405406 from MyBioSource.com

Description

Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex

Product Specs
ItemRecombinant Human Transmembrane prolyl 4-hydroxylase
CompanyMyBioSource.com
Price $1,010.00Supplier Page View Company Product Page
Catalog NumberMBS1405406
FormatLiquid containing glycerol; lyophilization may be available upon request
Molecular Weight70.51kD
NCBI Gene AliasesEGLN4, P4H-TM, PHD4, PH-4, HIFPH4, PH4
NCBI Full Gene Nameprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Domain/Region/Terminus82-563
Molecule NameTransmembrane prolyl 4-hydroxylase
HostE Coli or Yeast or Baculovirus or Mammalian Cell
TypeRecombinant Protein
PurityGreater than 90% as determined by SDS-PAGE
Size0.5 mg (Yeast)

Sequence

VHYSNGDESS DPGPQHRAQG PGPEPTLGPL TRLEGIKVGH ERKVQLVTDR DHFIRTLSLK PLLFEIPGFL TDEECRLIIH LAQMKGLQRS QILPTEEYEE AMSTMQVSQL DLFRLLDQNR DGHLQLREVL AQTRLGNGWW MTPESIQEMY AAIKADPDGD GVLSLQEFSN MDLRDFHKYM RSHKAESSEL VRNSHHTWLY QGEGAHHIMR AIRQRVLRLT RLSPEIVELS EPLQVVRYGE GGHYHAHVDS GPVYP

Add to Compare List