Description
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. This protein is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine
threonine kinase protein kinase B (PKB)
Akt and modulates PKB activity by enhancing the phosphorylation of PKB s regulatory sites. Alternative splicing results in two transcript variants encoding the same protein