Description
Product Characteristics: Purified native Human Cathepsin D protein
Bioactivity: 300 units/mg -One unit of activity is defined as the amount of enzyme which digests hemoglobin-releasing peptides which are soluble in 10 % TCA. The reaction is measured by an increase of an A280 of 1.0 per 60 minutes at 37o C. Substrate: acid denatured hemoglobin (0.2 % in reaction mixture). Bu er: 0.1 M formate, pH 3.3.
Protein Source: Human plasma
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Target Information: This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]