Fig 1: DUSP6 mediates SKA1 depletion-induced tumor suppression. (A and B), Transwell assay was used to assess the invasiveness and migration of cells transfected with indicated constructs. Data shown are mean from three independent experiments performed in triplicate. *P < 0.05. (C) Western blot analysis of E-cadherin and vimentin protein levels in cells transfected with indicated constructs after TGF-ß1 treatment. One representative experiment of three independent experiments are shown.
Fig 2: Analysis of the mRNA profiles of SKA1 knockdown and control 786-O cells. (A) Volcanic maps show the distribution of different genes between the sh-SKA1 and sh-Ctrl group. (B) Cluster diagrams show the aggregation of all samples and different genes at the expression level. (C) qRT-PCR analysis of DUSP6 mRNA expression in tumor and non-tumor renal tissues. (D) Kaplan-Meier curves for overall survival based on DUSP6 expression in ccRCC patients from TCGA-KIRC dataset (N = 516).
Supplier Page from Abcam for DUSP6 peptide