Description
CHMP4A(Chromatin-modifying protein 4a) belongs to the SNF7 family and functions aschromatin-modifying proteins. It probable core component of the endosomalsorting required for transport complex III (ESCRT-III) which is involved inmultivesicular bodies (MVBs) formation and sorting of endosomal cargoproteins into MVBs. Also during HIV-1 infection, the virus uses the ESCRT-IIIcomplex to mediate budding and exocytosis of viral proteins via theassociation of CHMP4 and a protein recruited by HIV-1 p6, which is present inviral Gag assembly and budding. CHMP4A expressed at higher level in heart,kidney, liver and skeletal muscle