Description
Gdf3 is a TGFβsuperfamily member belonging to the growth/differentiation factor family.Gdf3 is expressed in undifferentiated embryonic stem (ES) cells, adiposetissue and the brain. In ES cells, it maintains pluripotency and influencesearly cell fate decisions. For example, frog embryos injected with Gdf3develop a secondary dorsal axis and deletion of mouse Gdf3 can producedefects in the anterior visceral endoderm of the pregastrulation embryo