Description
IL36RN isa member of the IL-1 family of proteins. IL-1 family members include IL-1β,IL-1α, IL-1ra, IL-18 and IL-1F5-F10.All family members show a 12 β-strand,β-trefoil configuration, and all family members are believed to have arisenfrom a common ancestral gene that underwent multiple duplications. The human IL-36Ra/IL-1F5gene is in closest proximity to the gene for IL-1ra and is likely arelatively recent duplication of the IL-1ra gene