Description
HDAC10 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. HDAC10 belongs to class II of the histone deacetylase family that catalyzes the deacetylation of lysine residues in the N-terminal tail of histones and represses transcription in large multiprotein complexes with transcriptional co-repressors. Therefore, HDAC10 plays a role in transcriptional repression. HDAC10 interacts with HDAC3 in co-transfected embryonic kidney cells. Deletion analysis indicates that both the N- and C-terminal domains of HDAC10 bound HDAC3 independently