Description
INCENP or inner centromere protein antigens 135/155kDa is a constitutively binding centromere proteins and passenger, or transiently interacting, proteins. Theoverexpression of a truncation mutant of chicken INCENP and a chimeric CENPB:INCENP protein in mammalian cell culture disrupted both prometaphase chromosome alignment and completion of cytokinesis. INCENP forms a complex with the evolutionarily conserved family of Aurora B kinases which helps coordinate chromosome segregation, spindle behavior, and cytokinesis during mitosis