Description
Csf2 is amonomeric protein of 127 amino acids with two glycosylation sites. Theprotein is synthesized as a precursor of 144 amino acids, which included ahydrophobic secretory signal sequence at the aminoterminal end. The sugarmoiety is not required for the full spectrum of biological activities. Non-glycosylated and glycosylated Csf2 show the same activities in vitro. Fullyglycosylated Csf2 is biologically more active in vivo than the non-glycosylated protein. This protein is secreted together with other factors byT-cells and macrophages following cell activation by antigens or mitogens