Description
Il5ra isa 60 kDa hematopoietin receptor that plays a dominant role in eosinophilbiology. Mature mouse Il5ra consists of a 322 amino acid (aa) extracellular domain(ECD) with a WSxWS motif and a four cysteine motif, a 22 aa transmembrane segment,and a 54 aa cytoplasmic domain. Within the ECD, mouse Il5ra shares 71% and 86%aa sequence identity with human and rat Il5ra, respectively. Alternatesplicing of mouse Il5ra generates soluble secreted forms which function asIL-5 antagonists