Description
MAP4K2 is a serine/threonine protein kinase that is activated by TNFµ and interacts with the TNF receptor-associated factor 2 (TRAF2). MAP4K2 is upstream of MAP kinases and particularly activates the SAPK pathway. Although MAP4K2 is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. A mouse protein Rab8ip that has high homology to MAP4K2 can interact with the vesicular transport protein Rab8. Based on its interaction with Rab8, it is postulated that Rab8ip/MAP4K2 may modulate secretion in response to stress stimuli