Description
SCARB1 is a member of the scavenger receptorfamily. SCARB1 is expressed primarily in liver and non-placentalsteroidogenic tissues. It binds high density lipoproteins (LDL) and mediatesselective cholesterol uptake by a mechanism distinct from the LDL pathway.High density lipoproteins (HDLs) play a critical role in cholesterolmetabolism and their plasma concentrations are inversely correlated with riskfor atherosclerosis. SCARB1 is a key component in the reverse cholesteroltransport pathway and plays an important role in lipid metabolism