Recombinant Human Ubiquitin AMC Protein, CF U-550-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Ubiquitin AMC Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $384.00Supplier Page View Company Product Page
Catalog NumberU-550-050
Size50 ug
ApplicationsEnzyme Activity
Conjugate/Tag7-Amino-4-Methyl Coumarin
FormatSupplied as a solution in DMSO
Molecular Weight8.7 kDa
SpeciesHuman
Molecule NameUbiquitin
Source/Expression SystemE. coli-derived Recombinant Human Ubiquitin AMC Protein, CF
NCBI Full Gene Nameubiquitin B
NCBI Gene AliasesHEL-S-50
StorageProtect from light. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Identification of chemical scaffolds for targeting ubiquitin-specific protease 11 (USP11) through high-throughput virtual screeningJ Enzyme Inhib Med ChemJune 30, 2025Hobin Lee, Sunghoon Hurh, Soomin Kang, Jihwan Yoon, Jong-Ik Hwang, Derek T. Logan, Hong-Rae Kimassay The deubiquitinating enzyme (DUB) activity of USP11 was monitored using Ubiquitin AMC (Ub-AMC) (#U-550–050, R&D Systems, Minneapolis, MN, USA) as a fluorogenic substrate. Purified GST-USP11 (100 nM) was pre-incubated

(2) Drug resistance-associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activityThe Journal of biological chemistryMarch 1, 2025Smith CJ, Eavis H, Briggs C, Henrici R, Karpiyevich M, Ansbro MR, Hoshizaki J, van der Heden van Noort GJ, Ascher DB, Sutherland CJ, et al.

(3) Thiol-Reactive or Redox-Active: Revising a Repurposing Screen Led to a New Invalidation Pipeline and Identified a True Noncovalent Inhibitor Against Papain-like Protease from SARS-CoV-2ACS Pharmacology & Translational ScienceJanuary 10, 2025Maria Kuzikov, Stefano Morasso, Jeanette Reinshagen, Markus Wolf, Vittoria Monaco, Flora Cozzolino, Simona Golič Grdadolnik, Primož Šket, Janez Plavec, Daniela Iaconis, et al.sealed and incubated for 30 min at 25 °C, followed by adding 5 μL/0.5 μM Ubiquitin-AMC (R&D Systems #U-550-050) substrate. The fluorescence signal was measured after 30 min of incubation (Ex/Em = 340/460; EnVision,

(4) Suppressing Tymovirus replication in plants using a variant of ubiquitinPLoS pathogensJanuary 1, 2025De Silva A, Kim K, Weiland J, Hwang J, Chung J, Pereira HS, Patel TR, Teyra J, Patel A, Mira MM, et al.

(5) Proteasome associated function of UCH37 is evolutionarily conserved in Plasmodium parasitesScientific reportsNovember 27, 2024Hajisadeghian M, Geiger AM, Briggs C, Smith C, Artavanis-Tsakonas K.

(6) Redox control of the deubiquitinating enzyme Ubp2 regulates translation during stressThe Journal of biological chemistryNovember 1, 2024Santos CM, Cizubu BK, Okonkwo DA, Chen CY, Maske N, Snyder NA, Simões V, Washington EJ, Silva GM.

(7) Autoinhibition of ubiquitin-specific protease 8: Insights into domain interactions and mechanisms of regulationThe Journal of biological chemistryOctober 1, 2024Caba C, Black M, Liu Y, DaDalt AA, Mallare J, Fan L, Harding RJ, Wang YX, Vacratsis PO, Huang R, et al.

(8) Systematic Studies on the Anti-SARS-CoV-2 Mechanisms of Tea Polyphenol-Related Natural ProductsACS OmegaJune 4, 2024Chen-Wei Li, Tai-Ling Chao, Chin-Lan Lai, Cheng-Chin Lin, Max Yu-Chen Pan, Chieh-Ling Cheng, Chih-Jung Kuo, Lily Hui-Ching Wang, Sui-Yuan Chang, Po-Huang LiangZ-Arg-Leu-Arg-Gly-Gly-AMC (Cat. #79997, Bachem Bioscience, Switzerland) for proteolytic activity, Ub-AMC (Cat. #U550-050, Boston Biochem) for deubiquitinating activity, and ISG15-AMC (Cat. #U553-050, Boston Biochem) for deISGylation

(9) Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptidesProceedings of the National Academy of Sciences of the United States of AmericaMay 21, 2024King HR, Bycroft M, Nguyen TB, Kelly G, Vinogradov AA, Rowling PJE, Stott K, Ascher DB, Suga H, Itzhaki LS, et al.

(10) The BAP1 nuclear deubiquitinase is involved in the nonhomologous end-joining pathway of double-strand DNA repair through interaction with DNA-PKOncogeneApril 1, 2024Sato H, Ito T, Hayashi T, Kitano S, Erdjument-Bromage H, Bott MJ, Toyooka S, Zauderer M, Ladanyi M.

(11) Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1Nature communicationsJanuary 2, 2024Ren W, Xu Z, Chang Y, Ju F, Wu H, Liang Z, Zhao M, Wang N, Lin Y, Xu C, et al.

(12) Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesisPLoS pathogensDecember 1, 2023Bailey-Elkin BA, Knaap RCM, De Silva A, Boekhoud IM, Mous S, van Vught N, Khajehpour M, van den Born E, Kikkert M, Mark BL.

(13) Altered ubiquitin signaling induces Alzheimer's disease-like hallmarks in a three-dimensional human neural cell culture modelNature communicationsSeptember 22, 2023Maniv I, Sarji M, Bdarneh A, Feldman A, Ankawa R, Koren E, Magid-Gold I, Reis N, Soteriou D, Salomon-Zimri S, et al.

(14) Accelerating inhibitor discovery for deubiquitinating enzymesNature communicationsFebruary 8, 2023Chan WC, Liu X, Magin RS, Girardi NM, Ficarro SB, Hu W, Tarazona Guzman MI, Starnbach CA, Felix A, Adelmant G, et al.

(15) Targeting BAP1 with small compound inhibitor for colon cancer treatmentScientific reportsFebruary 8, 2023Kang M, Park SG, Lee SA, Kim S, Lee D, Shirbhate ME, Youn SY, Kim KM, Cha SS, Kwon J.

(16) Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinomaCell death and differentiationFebruary 1, 2023Cao YF, Xie L, Tong BB, Chu MY, Shi WQ, Li X, He JZ, Wang SH, Wu ZY, Deng DX, et al.

(17) USP14-regulated allostery of the human proteasome by time-resolved cryo-EMNatureMay 1, 2022Zhang S, Zou S, Yin D, Zhao L, Finley D, Wu Z, Mao Y.

(18) Repurposing the Pathogen Box compounds for identification of potent anti-malarials against blood stages of Plasmodium falciparum with PfUCHL3 inhibitory activityScientific reportsJanuary 18, 2022Bharti H, Singal A, Saini M, Cheema PS, Raza M, Kundu S, Nag A.

(19) Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2LeukemiaJanuary 1, 2022Yang J, Weisberg EL, Liu X, Magin RS, Chan WC, Hu B, Schauer NJ, Zhang S, Lamberto I, Doherty L, et al.

(20) A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like proteaseCell reportsSeptember 28, 2021Patchett S, Lv Z, Rut W, Békés M, Drag M, Olsen SK, Huang TT.

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Recombinant Human Ubiquitin AMC Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human Ubiquitin AMC Protein, CF from R&D Systems, a Bio-Techne Brand

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