Recombinant Human/Mouse/Rat UBE2M/Ubc12 Protein, CF E2-656-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human/Mouse/Rat UBE2M/Ubc12 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $391.00Supplier Page View Company Product Page
Catalog NumberE2-656-100
Size100 ug
ApplicationsEnzyme Activity
Conjugate/TagUnconjugated
FormatSupplied as a solution in HEPES, NaCl, TCEP and Glycerol
Purity>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain
Molecular Weight21 kDa
SpeciesHuman, Mouse, Rat
Molecule NameUBE2M/Ubc12
Source/Expression SystemE. coli-derived Recombinant Human/Mouse/Rat UBE2M/Ubc12 Protein, CF
NCBI Full Gene Nameubiquitin conjugating enzyme E2 M
NCBI Gene AliasesUBC12, hUbc12, UBC-RS2
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) A LisH-domain protein interaction map reveals a Lis1-ARIH2-dynein regulatory axisiScienceNovember 21, 2025Devanshi Gupta, Subbareddy MaddikaBiochem,Cat#BML-PW9425-0020 Nedd8 E1 protein,R&D systems,Cat#E-313-025 Nedd8 UBE2M,R&D systems,Cat#E2-656-100 Nedd8 purified,R&D systems,Cat#UL-812-500 ,, Deposited data,Deposited data,Deposited data ,, Human

(2) Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNFNatureApril 1, 2024Radko-Juettner S, Yue H, Myers JA, Carter RD, Robertson AN, Mittal P, Zhu Z, Hansen BS, Donovan KA, Hunkeler M, et al.

(3) Determining the Effects of Neddylation on Cullin-RING Ligase-Dependent Protein UbiquitinationCurr ProtocMarch 1, 2022Wang K, Liu X.no. UL‐812‐500)",2 μM "NAE (R&D Systems, cat. no. E‐313‐025)",0.25 μM "UBC12 (R&D Systems, cat. no. E2‐656‐100)",3 μM CUL2•RBX1 (see Basic Protocol 1 and Support Protocol),0.2 μM Composition of the Neddylation

(4) Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transferNature chemical biologyNovember 1, 2020Cathcart AM, Bird GH, Wales TE, Herce HD, Harvey EP, Hauseman ZJ, Newman CE, Adhikary U, Prew MS, Oo T, et al.

(5) Mdm2-mediated neddylation of pVHL blocks the induction of antiangiogenic factorsOncogeneJuly 1, 2020Wolf ER, Mabry AR, Damania B, Mayo LD.

(6) A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylationNature communicationsOctober 27, 2017Zhou H, Lu J, Liu L, Bernard D, Yang CY, Fernandez-Salas E, Chinnaswamy K, Layton S, Stuckey J, Yu Q, et al.

(7) SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase functioneLifeMay 5, 2017Coleman KE, Békés M, Chapman JR, Crist SB, Jones MJ, Ueberheide BM, Huang TT.

(8) The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activityThe Journal of biological chemistryJanuary 2, 2015Huang G, Towe CW, Choi L, Yonekawa Y, Bommeljé CC, Bains S, Rechler W, Hao B, Ramanathan Y, Singh B.

(9) SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1)The Journal of biological chemistryDecember 12, 2014Huang G, Stock C, Bommeljé CC, Weeda VB, Shah K, Bains S, Buss E, Shaha M, Rechler W, Ramanathan SY, et al.

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Recombinant Human/Mouse/Rat UBE2M/Ubc12 Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human/Mouse/Rat UBE2M/Ubc12 Protein, CF from R&D Systems, a Bio-Techne Brand

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