Human 20S Proteasome Protein, CF E-360-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemHuman 20S Proteasome Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $309.00Supplier Page View Company Product Page
Catalog NumberE-360-050
Size50 ug
ApplicationsEnzyme Activity
Conjugate/TagUnconjugated
FormatSupplied as a 0.2 µm filtered solution in HEPES, NaCl and DTT
Molecular Weight700 kDa
SpeciesHuman
Molecule Name20S Proteasome
Source/Expression SystemHuman Erythrocytes
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) SpectraSage unveils specific proteolytic patterns of 20S on mono-ubiquitylated Tau proteoforms involved in neurodegenerationChemical scienceSeptember 17, 2025Zingale GA, Pandino I, Trivellato D, Cavaterra D, Munari F, Grasso G, Bell PA, Oddone F, Bocedi A, Coletta M, et al.

(2) β-Amyloid impairs Proteasome structure and function. Proteasome activation mitigates amyloid induced toxicity and cognitive deficitsbioRxiv : the preprint server for biologyFebruary 4, 2025Davidson K, Bano M, Parker D, Osmulski P, Gaczynska M, Pickering AM.

(3) Molecular basis for the stepwise and faithful maturation of the 20S proteasomeScience advancesJanuary 10, 2025Han Y, Han Q, Tang Q, Zhang Y, Liu K.

(4) Anthricin-induced hyperactive proteasome and its molecular mechanismBiochemistry and Biophysics ReportsDecember 1, 2024Kotaro Sakamoto, Runa Fujimoto, Erina Kamiyama-Ando, Takatsugu Hirokawadifferent experimental groups. 2.3 Pull-down assay Human erythrocyte-derived 20S proteasome protein (E−360-050) and Biotin-PEG4-NHS (29114) were purchased from R&D Systems Inc. (MN, USA) and Cyman, respectively.

(5) Exploring the therapeutic potential of Aloin: unraveling neuroprotective and anticancer mechanisms, and strategies for enhanced stability and deliveryScientific reportsJuly 20, 2024Zimbone S, Romanucci V, Zarrelli A, Giuffrida ML, Sciacca MFM, Lanza V, Campagna T, Maugeri L, Petralia S, Consoli GML, et al.

(6) 20S proteasome enhancers prevent cytotoxic tubulin polymerization-promoting protein induced α-synuclein aggregationiScienceJuly 19, 2024Sophia D. Staerz, Charles Anamoah, Jetze J. Tepeproteins","Chemicals, peptides and recombinant proteins" ,, "Human 20S Proteasome Protein, CF",R&D Systems,E-360-050 Suc-Leu-Leu-Val-Tyr-AMC (Suc-LLVY-AMC),R&D Systems,S-280-05M Z-Leu-Leu-Glu-AMC (Z-LLE-AMC),Cayman Chemicals

(7) SARS-CoV-2 mutations affect antigen processing by the proteasome to alter CD8(+) T cell responsesHeliyonOctober 1, 2023Wellington D, Yin Z, Yu Z, Heilig R, Davis S, Fischer R, Felce SL, Antoun E, Hublitz P, Beveridge R, et al.

(8) Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP binding and hydrolysis via CDDO and its derivativesThe Journal of biological chemistryMarch 1, 2022Lee J, Pandey AK, Venkatesh S, Thilagavathi J, Honda T, Singh K, Suzuki CK.

(9) Insulin-Degrading Enzyme Is a Non Proteasomal Target of Carfilzomib and Affects the 20S Proteasome Inhibition by the DrugBiomoleculesFebruary 16, 2022Tundo GR, Sbardella D, Oddone F, Grasso G, Marini S, Atzori MG, Santoro AM, Milardi D, Bellia F, Macari G, et al.

(10) Hepatitis C virus induces oxidation and degradation of apolipoprotein B to enhance lipid accumulation and promote viral productionPLoS pathogensSeptember 1, 2021Wang B, Zhu Y, Yu C, Zhang C, Tang Q, Huang H, Zhao Z.

(11) Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer’s DiseaseJournal of Medicinal ChemistryAugust 12, 2021Min Jae Lee, Deepak Bhattarai, Hyeryung Jang, Ahreum Baek, In Jun Yeo, Seongsoo Lee, Zachary Miller, Sukyeong Lee, Jin Tae Hong, Dong-Eun Kim, et al.activity assay using purified human 20S proteasome (Boston Biochem: constitutive proteasome, Cat No. E-360-050; immunoproteasome, Cat No E-370-025), 50 nanograms of diluted purified human 20S proteasomes in 20S

(12) Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 aperturesPLoS biologyMarch 1, 2020Guan H, Wang Y, Yu T, Huang Y, Li M, Saeed AFUH, Perčulija V, Li D, Xiao J, Wang D, et al.

(13) A dual inhibitor of the proteasome catalytic subunits LMP2 and Y attenuates disease progression in mouse models of Alzheimer's diseaseScientific reportsDecember 5, 2019Yeo IJ, Lee MJ, Baek A, Miller Z, Bhattarai D, Baek YM, Jeong HJ, Kim YK, Kim DE, Hong JT, et al.

(14) Discovery of Immunoproteasome Inhibitors Using Large-Scale Covalent Virtual ScreeningMolecules (Basel, Switzerland)July 16, 2019Scarpino A, Bajusz D, Proj M, Gobec M, Sosič I, Gobec S, Ferenczy GG, Keserű GM.

(15) A new gold(I) complex-Au(PPh₃)PT is a deubiquitinase inhibitor and inhibits tumor growthEBioMedicineJanuary 1, 2019Li X, Huang Q, Long H, Zhang P, Su H, Liu J.

(16) REGγ Controls Hippo Signaling and Reciprocal NF-κB-YAP Regulation to Promote Colon CancerClinical cancer research : an official journal of the American Association for Cancer ResearchApril 15, 2018Wang Q, Gao X, Yu T, Yuan L, Dai J, Wang W, Chen G, Jiao C, Zhou W, Huang Q, et al.

(17) Piperlongumine and some of its analogs inhibit selectively the human immunoproteasome over the constitutive proteasomeBiochemical and biophysical research communicationsFebruary 12, 2018Bosc E, Nastri J, Lefort V, Valli M, Contiguiba F, Pioli R, Furlan M, Bolzani VDS, El Amri C, Reboud-Ravaux M.

(18) Immunoproteasome functions explained by divergence in cleavage specificity and regulationeLifeNovember 28, 2017Winter MB, La Greca F, Arastu-Kapur S, Caiazza F, Cimermancic P, Buchholz TJ, Anderl JL, Ravalin M, Bohn MF, Sali A, et al.

(19) A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigensThe Journal of clinical investigationJune 30, 2017Chang AY, Dao T, Gejman RS, Jarvis CA, Scott A, Dubrovsky L, Mathias MD, Korontsvit T, Zakhaleva V, Curcio M, et al.

(20) Diabetogenic agent alloxan is a proteasome inhibitorBiochemical and biophysical research communicationsJune 24, 2017Zhou W, Wei L, Xiao T, Lai C, Peng M, Xu L, Luo X, Deng S, Zhang F.

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Human 20S Proteasome Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Human 20S Proteasome Protein, CF from R&D Systems, a Bio-Techne Brand

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