Recombinant Human ISG15 AMC Protein, CF UL-553-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human ISG15 AMC Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $431.00Supplier Page View Company Product Page
Catalog NumberUL-553-050
StorageProtect from light. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening
NCBI Gene AliasesG1P2, IP17, UCRP, hUCRP, IFI15, IMD38
NCBI Full Gene NameISG15 ubiquitin like modifier
Source/Expression SystemE. coli-derived Recombinant Human ISG15 AMC Protein, CF
Molecule NameISG15/UCRP
SpeciesHuman
Molecular Weight18 kDa
FormatSupplied as a solution in HEPES, NaCl, Glycerol and DTT
Conjugate/Tag7-Amino-4-Methyl Coumarin
ApplicationsEnzyme Activity
Size50 ug

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(1) Mechanisms of USP18 deISGylation revealed by comparative analysis with its human paralog USP41bioRxiv : the preprint server for biologyMay 28, 2024Bonacci T, Bolhuis DL, Brown NG, Emanuele MJ.

(2) Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivoPLoS pathogensMarch 1, 2024van Huizen M, Bloeme-Ter Horst JR, de Gruyter HLM, Geurink PP, van der Heden van Noort GJ, Knaap RCM, Nelemans T, Ogando NS, Leijs AA, Urakova N, et al.

(4) Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter AssayACS central scienceJuly 28, 2021Ma C, Sacco MD, Xia Z, Lambrinidis G, Townsend JA, Hu Y, Meng X, Szeto T, Ba M, Zhang X, et al.optimized procedure.35 Ub-AMC and ISG15-AMC were purchased from Boston Biochem (catalog no. U-550-050 and UL-553-050, respectively). Compound Synthesis and Characterization Details for the synthesis procedure and characterization

(5) Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assaybioRxiv : the preprint server for biologyMarch 16, 2021Xia Z, Sacco MD, Ma C, Townsend JA, Kitamura N, Hu Y, Ba M, Szeto T, Zhang X, Meng X, et al.optimized procedure.27 Ub-AMC and ISG15-AMC were purchased from Boston Biochem (catalog # U-550-050 and UL-553-050 respectively). Compound synthesis and characterization. Details for the synthesis procedure and characterization

(6) Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9XProceedings of the National Academy of Sciences of the United States of AmericaApril 9, 2019Paudel P, Zhang Q, Leung C, Greenberg HC, Guo Y, Chern YH, Dong A, Li Y, Vedadi M, Zhuang Z, et al.

(7) A family of unconventional deubiquitinases with modular chain specificity determinantsNature communicationsFebruary 23, 2018Hermanns T, Pichlo C, Woiwode I, Klopffleisch K, Witting KF, Ovaa H, Baumann U, Hofmann K.

(9) A Wolbachia deubiquitylating enzyme induces cytoplasmic incompatibilityNature microbiologyMarch 1, 2017Beckmann JF, Ronau JA, Hochstrasser M.

(13) High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion systemBMC biotechnologyAugust 23, 2012Basters A, Ketscher L, Deuerling E, Arkona C, Rademann J, Knobeloch KP, Fritz G.

Recombinant Human ISG15 AMC Protein, CF from R&D Systems, a Bio-Techne Brand