Description
FCER2, the lowaffinity receptor for IgE, belongs to the C-type lectin structural family andplays a role in the regulation of IgE synthesis and IgE mediated activities.It is found both as a transmembrane receptor protein and in a soluble form,which is generated by proteolytic cleavage of membrane bound FCER2. Thepredominant soluble form of FCER2 (sCD23) consists of 172 amino acidscorresponding to the extracellular domain of the full length precursor.sCD23, in addition to binding IgE, also exerts a number of IgE independentactivities, such as promoting the activation and differentiation of B-cellsand stimulating the release of pro-inflammatory cytokines from monocytes