Description
H60a wasoriginally described as an immunodominant histocompatibility antigen that isexpressed in BALB mice but not in B6 mice. More recently it was reported to functionas a ligand for mouse NKG2D, an activating receptor found on NK cells, onsome T cell subsets, and on stimulated macrophages. H60a shares approximately25 percent amino acid identity with the Rae-1 family, a small group ofproteins that also function as ligands for mouse NKG2D. H60a and the Rae-1proteins are distantly related to MHC class I proteins, but they possessesonly the α1 and α2 Ig-like domains, and have no capacity to bind peptide orinteract with β2-microglobulin