GSK-J4 (hydrochloride) 12073 from Cayman Chemical

Product Specs
ItemGSK-J4 (hydrochloride)
CompanyCayman Chemical
Price $134.00Supplier Page View Company Product Page
Catalog Number12073
Size10 mg
Research AreaEpigenetics, Transcription, & Translation, Erasers, Histone Demethylation, Immunology & Inflammation, Innate Immunity
FormatA crystalline solid
Molecular Weight454
Purity≥98%
Storage-20
FormulaC24H27N5O2 • HCl
OriginUSA
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) A mouse model of Weaver syndrome displays overgrowth and excess osteogenesis reversible with KDM6A/6B inhibitionJCI InsightJanuary 9, 2024Christine W. Gao, WanYing Lin, Ryan C. Riddle, Priyanka Kushwaha, Leandros Boukas, Hans T. Björnsson, Kasper D. Hansen, Jill A. FahrnerPrimers are listed in Supplemental Table 2B. GSK-J4 treatment. GSK-J4 crystalline solid (Cayman, 12073) was reconstituted in dimethyl sulfoxide (Sigma-Aldrich, D2650) to a stock concentration of 10 mM. BM-MSCs

(2) Novel mouse model of Weaver syndrome displays overgrowth and excess osteogenesis reversible with KDM6A/6B inhibitionbioRxivJuly 7, 2023Christine W Gao, WanYing Lin, Ryan C Riddle, Priyanka Kushwaha, Leandros Boukas, Hans T Björnsson, Kasper D Hansen, Jill A FahrnerViiA 7 Real-Time PCR System. Primers are listed in Supplemental Table 2B. GSK-J4 treatment: GSK-J4 crystalline solid (Cayman 12073) was reconstituted in dimethyl sulfoxide (Sigma-Aldrich D2650) to a stock concentration of 10 mM. BM-MSCs

(3) Response and resistance to CDK12 inhibition in aggressive B-cell lymphomasHaematologicaMay 1, 2022Jing Gao et al.17488), GSK591 (Cayman Chemical, 18354), GSK864 (Cayman Chemical, 18762), GSK-J4 (Cayman Chemical, 12073), GSK-LSD1 (Cayman Chemical, 16439), I-CBP112 (Cayman Chemical, 14468), JQ1 (Cayman Chemical, 11187),

(4) NFAT5 Amplifies Antipathogen Responses by Enhancing Chromatin Accessibility, H3K27 Demethylation, and Transcription Factor RecruitmentJournal of immunology (Baltimore, Md. : 1950)June 1, 2021Lunazzi G, Buxadé M, Riera-Borrull M, Higuera L, Bonnin S, Huerga Encabo H, Gaggero S, Reyes-Garau D, Company C, Cozzuto L, et al.with the same results. GSK-J4 (hydrochloride) was from Tocris Bioscience (4594) or from Cayman Chemical (12073). GSK-126 (15415) and UNC1999 (14621) were from Cayman Chemical. These inhibitors were used at 10 mM.

(5) Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphomaCell reportsMarch 16, 2021Zhao X, Wang MY, Jiang H, Lwin T, Park PM, Gao J, Meads MB, Ren Y, Li T, Sun J, et al.17488 GSK591,Cayman Chemical,Item# 18354 GSK864,Cayman Chemical,Item# 18762 GSK-J4,Cayman Chemical,Item# 12073 GSK-LSD1,Cayman Chemical,Item# 16439 Ibrutinib,Selleckchem,Cat# S2680 I-CBP112,Cayman Chemical,Item#

(6) A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibitionScientific reportsFebruary 25, 2021Kitajima S, Sun W, Lee KL, Ho JC, Oyadomari S, Okamoto T, Masai H, Poellinger L, Kato H.media (ATCC, PCS-400-030 and PCS-400-040) and used within tenfold expansion in cell number. GSK-J4 (12073) and CPI-455 (22127) were obtained from Cayman Chemical (Ann Arbor, MI, USA). Tunicamycin (T-7765) was

(7) Pharmacological targeting of KDM6A and KDM6B, as a novel therapeutic strategy for treating craniosynostosis in Saethre-Chotzen syndromeStem Cell Research & TherapyDecember 1, 2020Clara Pribadi, Esther Camp, Dimitrios Cakouros, Peter Anderson, Carlotta Glackin, Stan Gronthoslevels was 72 h before changing the media to osteogenic inductive media. GSK-J4 treatment GSK-J4 (Cat# 12073, Cayman Chemical, Ann Arbor, MI, US) was reconstituted in DMSO and stored at − 80 °C. Cells were seeded

(8) Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine GliomasCancer cellSeptember 14, 2020Chung C, Sweha SR, Pratt D, Tamrazi B, Panwalkar P, Banda A, Bayliss J, Hawes D, Yang F, Lee HJ, et al.Matrix),Corning,Cat# 356234 "D-Luciferin, Potassium Salt",GoldBio,Cat# LUCK-1G GSK-J4,Cayman Chem.,Cat# 12073 GSK-J5,Cayman Chem.,Cat# 12074 DON (6-Diazo-5-oxo-L-norleucine),Cayman Chem.,Cat# 17580 2-DG (2-Deoxy-D-glucose),Cayman

(9) EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathwaysScience advancesAugust 1, 2020Wang J, Yang L, Dong C, Wang J, Xu L, Qiu Y, Weng Q, Zhao C, Xin M, Lu QR.pharmacological inhibitor treatment The histone H3 lysine 27 (H3K27) demethylase JMJD3 inhibitor GSK-J4 (Cayman, 12073), WNT inhibitor Wnt C59 (Cayman, 16644), and BMP inhibitor LDN193189 (Cayman, 11802) were dissolved

(10) BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma ModelsCancer cellMay 13, 2019Zhao X, Ren Y, Lawlor M, Shah BD, Park PMC, Lwin T, Wang X, Liu K, Wang M, Gao J, et al.S2711 SGC0946,Cayman Chemical,Cat# 13967 OJI1,Dana-Farber Cancer Institute Qi Jun lab,NA GSK-J4,Cayman Chemical,Cat# 12073 UNC0642,Cayman Chemical,Cat# 14604 Lumpib,Selleckchem,Cat# S1069 INCB059872,"Incyte Corporation (Wilmington,

(11) Role of Serum Amyloid A, Granulocyte-Macrophage Colony-Stimulating Factor, and Bone Marrow Granulocyte-Monocyte Precursor Expansion in Segmented Filamentous Bacterium-Mediated Protection from Entamoeba histolyticaInfection and immunityOctober 1, 2016Burgess SL, Saleh M, Cowardin CA, Buonomo E, Noor Z, Watanabe K, Abhyankar M, Lajoie S, Wills-Karp M, Petri WA Jr.ng/ml; InvivoGen), SAA (10 ␮g; PeproTech, 300-13), or SAA with GSK-J5 or GSK-J4 (2.5 mg; Cayman Chemical, 12073 and 12074) and then harvested in RNAlater (Ambion, Austin, TX). Mice were treated intraperitoneally on

(12) UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemiaGenes & developmentMarch 1, 2016Benyoucef A, Palii CG, Wang C, Porter CJ, Chu A, Dai F, Tremblay V, Rakopoulos P, Singh K, Huang S, et al.was obtained initially from the Structural Genomics Consortium and then from Cayman Chemicals (no. 12073) and used at the concentrations indicated. T-ALL cell lines were treated with GSK-J4 for 48 h. Primary

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GSK-J4 (hydrochloride) from Cayman Chemical

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GSK-J4 (hydrochloride) from Cayman Chemical

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