Description
Alpha-1-antitrypsin (A1AT) is a serine protease inhibitor that inhibits the catalytic domain of elastase, plasmin, collagenase, thrombin, leucocytic proteases, trypsin, chymotrypsin, and plasminogen activator. Defects in the A1AT gene can lead to emphysema or liver disease. Increased levels of serum A1AT are found in cases of lung and prostate cancers and as an acute phase response to tissue necrosis and inflammation.
Recombinant Human A1AT produced in E. coli is a single, non-glycosylated polypeptide chain containing 393 amino acids (aa 25-418) with a molecular weight of 44.4kDa