Description
Insulin-like growth factor 1 receptor (IGF-1R/CD221) is a membrane-associated tyrosine kinase receptor that plays an important role in cell growth, transformation, and protection of cells from a variety of apoptotic stimuli. IGF-1R (CD221) is a tetrameric receptor consisting of two -subunits and two transmembrane β- subunits that are linked by disulfide bonds.The - subunits are extracellular and bind IGF. Each transmembrane β-subunit contains an intracellular tyrosine kinase domain