Description
Hsp60 is a mitochondrial chaperonin responsible for transportation and refolding of proteins from the cytoplasm directly into the mitochondrial matrix. Hsp60 is regulated by the Hsp10 cochaperonin. Hsp10 coordinates the ATPase activity of the Hsp60 subunits in order to allow the release of bound polypeptide in a manner that is productive for its correct folding.
Recombinant Human GroEL (Hsp60) produced in E. coli is a single, nonglycosylated polypeptide chain containing 553 amino acids with a molecular weight of 63kDa