Description
The effects of IL-6 are mediated by a functional IL- 6 receptor (IL-6R), which consists in a heterodimer formed by an IL-6-binding α chain (IL-6Rα) and a signal- transducing subunit, gp130 or IL-6Rβ. Binding of IL-6 to the IL-6Rα induces homodimerization of two gp130 molecules, leading to intracellular signals