Description
Troponin T (TnT) is the tropomyosinbinding subunit of the troponin complex which is situated on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentrations. Mutations in the TNNT2 gene are associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy and hypertrophic cardiomyopathy.
Recombinant Human TnT produced in E. coli is a single, non-glycosylated polypeptide chain containing 305 amino acids (aa 1-285) with a molecular weight of 36.4 kDa. It is fused to a 20-amino acid His-tag at the N-terminus