Description
Oncostatin M is produced by monocytes and T-cells after cell activation, adherent macrophages, and various T- cell lines. Oncostatin M is a member of the IL6-related cytokine subfamily that includes IL6, IL11, LIF, CNTF and CT-1.Oncostatin M mediates its bioactivities through two different heterodimer receptors. They both involve gp130 as a signal transducing moiety, which is found also in receptors for a number of other cytokines