Description
RGS16, also known as regulator of G-protein signaling 16, belongs to 'regulator of G protein signaling' family and negatively regulates G protein coupled receptor signalling. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP bound form. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. Recombinant RGS16 protein was expressed in E.coli and purified by using conventional chromatography techniques