Description
Entry of human immunodeficiency virus (HIV- 1) into target T lymphocytes is known to be mediated by the viral envelope glycoproteins gp120/gp41. The glycoprotein gp41 is thought to form a six-helix bundle during viral fusion with the target cell. This bundle is comprised of three helical regions (from the heptad repeat 2, or HR2, region of gp41) bound to an inner, trimeric, coiled-coil core (from the HR1 region)