Description
HCV nonstructural NS4A helps to anchor NS3 to the surface of the microsomal membrane by mutual association of these two proteins. Furthermore, the NS3- NS4A complex associates with NS4B, NS5A, and NS5B to form a complex structure which may be involved in virus replication. These observations may imply that NS4A plays an important role in complex formation. Recently, it was reported that NS4A is necessary for cleavage at the 4B-5A site and that it enhances cleavage at NS3- dependent cleavage sites