Description
Human interleukin 4 receptor alpha (IL-4Rα) is a Type I transmembrane and a Type I cytokine receptor. The recombinant IL-4Rα protein dimer (CSP-25219-01) is a cis-homodimer (cis-dimer) and contains a IL-4Rα extracellular domain (UniProt# P24394, amino acids Met26-His232) fused with a proprietary cis-dimer motif followed by a His tag at the C-terminus. This dimeric protein is expressed in HEK293T cells. The recombinant human IL-4Rα protein dimer is bioactive and can bind to interleukin 4 (IL-4). It also binds IL-4Rα-specific antibodies. This IL-4Rα protein dimer can be used as an antigen for in vitro assays and antibody screening, and as an immunogen for immunization to generate antibodies targeting more conformational epitopes