Description
Human cluster of differentiation 117 (CD117), also known as KIT or c-Kit, is a member of the Type III receptor tyrosine kinase family. The recombinant CD117 protein dimer (CSP-25123-04) is a cis-homodimer (cis-dimer) and contains a CD117 extracellular domain (UniProt# P10721, amino acids Ser25-Pro524) fused with a proprietary cis-dimer motif followed by a Fc at the C-terminus. This dimeric protein is expressed in HEK293T cells. The recombinant human CD117 protein dimer is bioactive and can bind to stem cell factor (SCF). It also binds CD117-specific antibodies. This CD117 dimer can be used as an antigen for in vitro assays and antibody screening, and as an immunogen for immunization to generate antibodies targeting more conformational epitopes