Description
Human fibroblast growth factor receptor 1 (FGFR1) is a cell surface receptor belonging to the immunoglobulin superfamily, functioning as a receptor tyrosine kinase (RTK). FGFR1 can form a ligand-dependent and ligand-independent dimer. The recombinant FGFR1 dimer protein (CSP-25129-03) is a cis-homodimer (cis-dimer) and contains a FGFR1 extracellular domain (UniProt# P11362, amino acids Arg22-Glu376) fused with a proprietary dimer motif followed by a tandem His-Avi tag at the C-terminus. This dimeric protein is expressed in HEK293 cells. The recombinant human FGFR1 dimer protein is bioactive and can bind to fibroblast growth factor 1 (FGF-1). It also binds FGFR1-specific antibodies. This FGFR1 dimer can be used as an antigen for in vitro assays and antibody screening, and as an immunogen for immunization to generate antibodies targeting more conformational epitopes