Description
Human fibroblast growth factor receptor 4 (FGFR4) is a cell surface receptor belonging to the immunoglobulin superfamily functioning as a receptor tyrosine kinase (RTK). FGFR1 can form ligand-dependent and ligand-independent dimers. The recombinant FGFR4 protein dimer (CSP-25132-03) is a cis-homodimer (cis-dimer) and contains a FGFR4 extracellular domain (UniProt# P22455, amino acids Leu22-Asp369) fused with a proprietary cis-dimer motif followed by a tandem His-Avi tag at the C-terminus. This dimeric protein is expressed in HEK293T cells. The recombinant human FGFR4 protein dimer is bioactive and can bind to fibroblast growth factor 1 (FGF-1). It also binds FGFR4-specific antibodies. This FGFR4 dimer can be used as an antigen for in vitro assays and antibody screening, and as an immunogen for immunization to generate antibodies targeting more conformational epitopes