Description
GLP-1(7-37) acetate is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.In VivoGLP-1(7-37) (0.5, 5 or 50 pmol/min/kg) infused during the second hour of a 2-hour 11-mM hyperglycemic clamp produces a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion in rats. Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats weighing 300 to 350 g with glucose IV at a variable\nrate for 7 hours to maintain plasma glucose concentration at 11 mM. Dosage: 5 pmol/min/kg. Administration: IV from 1 hour through 7 hours. Result: Produced a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle. Animal Model: Male Sprague-Dawley rats weighing 300 to 350 g with maintained plasma glucose concentration at 11 mM. Dosage: 0.5, 5 or 50 pmol/min/kg. Administration: IV during the second hour of a 2-hour 11-mmol/L hyperglycemic clamp. Result: Produced a dose-related enhancement of the glucose-stimulated increase in plasma insulin concentration and an increased rate of glucose infusion.Form:Solid