Colivelin HY-P1061 from MedChemExpress

Product Specs
ItemColivelin
CompanyMedChemExpress
Price $190.00Supplier Page View Company Product Page
Catalog NumberHY-P1061
Size500 µg
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.92%
TypeChemical
Research AreaNeurological Disease

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(1) Integrative multiomics analysis identifies RARRES2 as a regulator of keloid pathogenesis through STAT3/HSPG2 signaling axisiScienceMay 15, 2026Wenkang Luan, Shujun Fan, Hanyi Jiang, Dongwen Jiang, Jinxiu Yang, Leren Heand recombinant proteins" ,, Chemerin,MedChemExpress,Cat#HY-P70099 Colivelin,MedChemExpress,Cat#HY-P1061 Stattic,MedChemExpress,Cat#HY-13818 Cell counting kit-8,Beyotime,Cat#C0037 Bleomycin,MACKLIN,Cat#9041-93-4 ,, Critical

(2) TTPAL inhibits the progression of breast cancer and reprograms tumor-associated macrophages by inhibiting JAK2/STAT3 signaling pathwayBreast Cancer ResearchApril 5, 2026Lingfang Du, Lingyun Zhu, Yang Yang, Lili Pan, Ting Lei, Jun Zhang, Shuang Yao, Guanghua Luo, Xiaoying Zhangrespectively. The culture medium was replaced with medium containing 18 μΜ concentrations of Colivelin (HY-P1061, MCE) for 6 h. Cell growth was monitored by CCK-8 assay according to the manufacturer’s instruction

(3) Microglial Inhibition Promotes Proliferation and Differentiation of Neural Stem Cells via STAT3/SDF-1/CXCR4 Signaling Pathway in Hypoxic-Ischemic EncephalopathyGliaMarch 26, 2026Ao Ding, Guiqin Duan, Mingwei Zhu, Li Chen, Jie Luo, Ting Tan, Zilin Li, Wenhui Wang, Jun Wang, Yuan Chen, et al.stattic (MedChemExpress, HY‐138185; 5 mg/kg; Alhazzani et al. 2021), and colivelin (MedChemExpress, HY‐P1061; 1 mg/kg; Zhao et al. 2019) were dissolved in a vehicle composed by 10% DMSO, 40% PEG300, 5% Tween‐80,

(4) Ginsenoside Rh2 Suppresses the Fanconi Anemia Pathway by Inhibiting NF-κB-Mediated FANCL Transcription in Bladder CancerDose ResponseDecember 18, 2025Chen Li, Guanglin Lv, Zhuang Xiong, Zhenfan Wangused at 1 µg/mL for 12 h to trigger the ribotoxic-stress-JNK axis. Colivelin (MedChemExpress, Cat. HY-P1061) was used at 1 µM for 6 h to activate STAT3. For USP1 knockdown, siRNA duplexes targeting human USP1

(5) Effect of Dipyridamole on Experimental Autoimmune Uveitis: Reprogrammed Immune Cell Landscape and Reduced Th17 PathogenicityInvestigative ophthalmology & visual scienceDecember 1, 2025Chen B, Huang Z, Chen J, Wu Y, Lv J, Wen Y, Wu X, Zhang X, Lin H, Su W.Sigma-Aldrich, St. Louis, MO, USA) was used as a specific PDE4 inhibitor at 10 µM. Colivelin (Cat. no. HY-P1061; MedChemExpress) was used as a STAT3 activator at 0.5 µM. After stimulation, cells were cultured at

(6) α-hederin Targets USP5 to Inhibit Colorectal Tumorigenesis by Disrupting STAT3 DeubiquitinationInternational Journal of Biological SciencesOctober 20, 2025Hui Feng, Qijuan Wang, Liu Li, Lihuiping Tao, Shuhong Zeng, Ziwen Li, Minmin Fan, Chengtao Yu, Dongdong Sun, Weixing Shen, et al.(Cambridge, UK). Cycloheximide (HY-12320), Pronase E (HY-114158), Stattic (HY-13818), and Colivelin (HY-P1061) were obtained from MedChemExpress (Monmouth Junction, NJ, USA). The 3-(4,5-dimethylthiazol-2-yl)-2,5

(7) VISTA expressed on tumor cells is regulated by m6A and influences immune microenvironment through STAT3/CCL22 in NSCLCJ Transl MedOctober 2, 2025Hao Xu, Kaikai Shen, Bei Jiang, Qiuli Xu, Bingbing Li, Zhangmin Ke, Qinpei Cheng, Suhua Zhu, Dong Wang, Yong Song, et al.purchased from AbMole Bioscience. CellTrace™ Violet (C34571) was purchased from ThermoFisher. Colivelin (HY-P1061) was purchased from MedChemExpress. Matrigel matrix (356234) was purchased from Fcmacs Biotech. Puromycin

(8) SMP30 Attenuates Lens Epithelial Cells Pyroptosis of Cataract via the Downregulation of p-STAT3J Inflamm ResSeptember 8, 2025Yongshun Liang, Qingqiao Gan, Xin Zhong, Tian Lan, Yingqin Yang, Lixia Lin, Chengye Tang, Hao Liangpuromycin. The manufacturer’s recommendations were followed when using the STAT3 agonist Colivelin (HY-P1061, MCE, USA) and inhibitor Stattic (HY-13818, MCE, USA). Transmission Electron Microscope The rats were

(9) SMP30 Attenuates Lens Epithelial Cells Pyroptosis of Cataract via the Downregulation of p-STAT3Journal of Inflammation ResearchSeptember 8, 2025Yongshun Liang, Qingqiao Gan, Xin Zhong, Tian Lan, Yingqin Yang, Lixia Lin, Chengye Tang, Hao Liangpuromycin. The manufacturer’s recommendations were followed when using the STAT3 agonist Colivelin (HY-P1061, MCE, USA) and inhibitor Stattic (HY-13818, MCE, USA). Transmission Electron Microscope The rats were

(10) Siramesine induced cell death of glioblastoma through inactivating the STAT3-MGMT signaling pathwayJ Transl MedJuly 10, 2025Xiaohang Cui, Anhui Yao, Jinquan Lv, Chi Zhang, Yue Chen, Tingjie Mei, Hengzeng Li, Yahui Wu, Liyun JiaSelleck Chemicals Co., Ltd.; Cat. No. S1237), Colivelin (MedChemExpress LLC Co., Ltd; Shanghai, China, Cat. No. HY-P1061), AG490 (MedChemExpress LLC Co., Cat. No. HY-12000), C188-9 (MedChemExpress LLC Co., Ltd; Shanghai,

(11) Targeting legumain-mediated cell-cell interaction sensitizes glioblastoma to immunotherapy in preclinical modelsJournal of Clinical InvestigationMay 15, 2025Lizhi Pang, Songlin Guo, Yuyun Huang, Fatima Khan, Yang Liu, Fei Zhou, Justin D. Lathia, Peiwen ChenRaw264.7 macrophages, mouse BMDMs, and THP1 macrophages with a potent STAT3 activator, Colivelin (MCE, HY-P1061), in addition to LGMN and AR-A014418. We found that the blocking of LGMN-induced macrophage migration

(12) Modulation of senescent Lepr+ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progressionStem Cell Res TherMay 5, 2025Fu-Hao Yu, Bo-Feng Yin, Ming-Yu Liu, Wen-Jing Zhang, Zhi-Dong Zhao, Lei Wang, Xiao-Tong Li, Pei-Lin Li, Zhi-Ling Li, Run-Xiang Xu, et al.Louis, USA). Allo-aca (HY-P3212), leptin (HY-P7232), FGF7 (HY-P70597), Stattic (HY-13818) and colivelin (HY-P1061) were purchased from MedChemExpress (New Jersey, USA). ACLT OA animal models Anterior cruciate ligament

(13) Single-cell multi-omics analysis reveals the mechanism of action of a novel antioxidant polyphenol nanoparticle loaded with STAT3 agonist in mediating cardiomyocyte ferroptosis to ameliorate age-related heart failureJ NanobiotechnologyMarch 29, 2025Haoyuan Zheng, Yuan Tian, Dongyu Li, Yanxiao Liangmixed with 100 μL of ethanol. Subsequently, 2 mg of the STAT3 agonist Colivelin (referred to as Col, HY-P1061, MedChemExpress, USA) was added to the mixture and vigorously stirred at 30 ℃. The nanoparticles were

(14) Targeting legumain-mediated cell-cell interaction sensitizes glioblastoma to immunotherapy in preclinical modelsJ Clin InvestMarch 25, 2025Lizhi Pang, Songlin Guo, Yuyun Huang, Fatima Khan, Yang Liu, Fei Zhou, Justin D. Lathia, Peiwen ChenRaw264.7 macrophages, mouse BMDMs, and THP1 macrophages with a potent STAT3 activator, Colivelin (MCE, HY-P1061), in addition to LGMN and AR-A014418. We found that the blocking of LGMN-induced macrophage migration

(15) MAZ-mediated LAMA5 transcription activation promotes gastric cancer progression through the STAT3 signalingFunct Integr GenomicsMarch 12, 2025Yu Wang, Jiazhong Xu, Hongxia Zhang, Xiaobo Guo, Hongjun Liu, Qinhui Suncells. AGS and HGC27 cells infected with sh-LAMA5 were pretreated with 0.5 µM STAT3 activator Colivelin (HY-P1061, MedChemExpress, Monmouth Junction, NJ, USA) (Chiu et al. 2016) or DMSO for 1 h for subsequent experiments. Cell

(16) Esketamine attenuates traumatic brain injury by modulating STAT3-mediated Glycolysis and immune responsesBMC NeurosciMarch 7, 2025Yufang Liu, Zheng Gong, Longfei Zhang, Xian Yang, Jie Zhu, Xin Zhou, Xingzhi Liaowere also cultured under Th17-polarizing conditions with or without 0.5 µM colivelin (MedChemExpress, HY-P1061), a STAT3 activator. RAW264.7 cells were treated with LPS (1 µg/mL) in the presence or absence of 2-deoxyglucose

(17) Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cellsWorld Journal of Stem CellsNovember 26, 2024Wan-Yu Zhang, Han-Bi Wang, Cheng-Yan Deng(STAT3), the STAT3 inhibitor Stattic (HY-13818, MedChemExpress, Junction, NJ) or agonist colivelin (HY-P1061, MedChemExpress) was added to HucMSCs. Wound healing and Transwell assays For the wound healing assay,

(18) Myeloid-derived suppressor cells cross-talk with B10 cells by BAFF/BAFF-R pathway to promote immunosuppression in cervical cancerCancer immunology, immunotherapy : CIIJanuary 1, 2023Jianyi D, Haili G, Bo Y, Meiqin Y, Baoyou H, Haoran H, Fang L, Qingliang Z, Lingfei H.with MDSCs in the presence or absence of 5 μM WP1066 (MCE, No. HY-15312) or 0.5 μM colivelin (MCE, No. HY-P1061). Finally, the differentiation ratio of B10 cells induced by MDSCs was detected by FACS, and the phenotype

(19) MFG-E8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by STAT3 regulating the selective polarization of microgliaThe International journal of neuroscienceJanuary 1, 2021Fang YY, Zhang JH.

(20) Upregulation of HSP72 attenuates tendon adhesion by regulating fibroblast proliferation and collagen production via blockade of the STAT3 signaling pathwayCellular signallingJuly 1, 2020Pan Z, Wu Q, Xie Z, Wu Q, Tan X, Wang X.

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Colivelin from MedChemExpress

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Colivelin from MedChemExpress

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