TGF beta 1/TGFB1 Protein, Human (HEK293) HY-P70543 from MedChemExpress

Product Specs
ItemTGF beta 1/TGFB1 Protein, Human (HEK293)
CompanyMedChemExpress
Price $340.00Supplier Page View Company Product Page
Catalog NumberHY-P70543
TypeProtein
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Size20 µg
SpeciesHuman

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(1) YAP1 converts circELP2-mediated biochemical signals to mechanical forces through promoting cytoskeleton remodeling in pulmonary fibrosisInternational Journal of Biological SciencesApril 8, 2026Ruiqiong Li, Songzi Zhang, Jinjin Zhang, Haitong Zhang, Yujie Wang, Changjun Lv, Bo Liu, Lihua Ren, Xiaodong Song, Fang Wangserum and placed in an incubator at 37 °C and 5% CO2. MRC-5 cell treated with 5 ng/mL TGF-β1 (MCE, HY P70543) for 48 h was used as the cell model of pulmonary fibrosis. In the gain- and loss-of-function experiments,

(2) Abrine targets ERK to suppress EMT and lung metastasis model via MAPKs and Nrf2/Keap-1/HO-1 signalingFrontiers in ImmunologyMarch 27, 2026Yufang Shen, Linyu Xiao, Lina Liu, Lianting Liao, Xianmin Zou, Pengfei Shen, Jinlong Zhao, Renyikun Yuan, Hongwei Gao, Chun Yaoinstruments Abrine (purchased from Chengdu Pui Fa Technology Development Co., Ltd., purity: ≥98%); TGF-β1 (#HY-P70543), Sch772984 (#HY-50846), and Gefitinib (#ZD1839) purchased from MedChemExpress (MCE Company, Shanghai,

(3) Diverse roles of SERPINE1 in regulating cellular proliferation and invasionInt J OncolMarch 13, 2026Wei Wang, Pengfei Zhao, Tian Wang, Weijing Wu, Jing Li, Qiang Huang, Jing Momofour biological replicates. The cells were treated with 0.5 ng/ml recombinant human TGF-β1 (cat. no. HY-P70543; MedChemExpress) or vehicle (4 mM HCl supplemented with 0.1% BSA) for 24 h to determine how exogenous

(4) A novel kinase inhibitor, Regorafenib, blocks EGFR-dependent signaling to repress tumour metastasis in human triple-negative breast cancersFront Cell Dev BiolMarch 3, 2026Ludong Zhao, Chunxin Wang, Yanzhi Wang, Meijing Liu, Hongyu Du, Xiaohui Chu, Wenqiang Yang, Wei Zhao, Guan Wang, Bo Zhang, et al.antibodies Regorafenib (HY-10331), HGF (HY-P7121), BAY 60-6583 (HY-103171), Dehydroepiandrosteron (HY-100197), TGF-β1 (HY-p70543) were purchased from MedChemExpress (Monmouth Junction, NJ, USA). TSFSILMSPDSPD peptides were synthesized

(5) Dahuang Zhechong pill alleviates pulmonary fibrosis by inhibiting apoptosis and epithelial-mesenchymal transition of type II alveolar epithelial cells in vitro and in vivoJournal of Traditional and Complementary MedicineMarch 1, 2026Fang Sun, Zhaochu Wu, Song Cai, Xiaoming Xing, Jing Wang, Lishan Zhangpurchased from China Beyotime Biotechnology Co., Ltd. (Shanghai, China). DMOG (#HY-15893), TGF-β1 (#HY-P70543), and SAG (#HY-12848) were purchased from MCE, USA. The following antibodies were purchased from Shanghai

(6) Abietane-Type Diterpenoids from the Resin of Pinus yunnanensis and Their Potential Anti-Renal Fibrosis ActivitiesMoleculesFebruary 14, 2026Cheng-Tian Tao, Jing Liu, Li Wan, Yong-Xian Cheng24 h, cells were serum-starved for 6 h and then incubated with recombinant human TGF-β1 (10 ng/mL; HY-P70543, MedChemExpress, San Jose, CA, USA) for 48 h with or without different concentrations of compounds.

(7) Anti-Fibrotic and Anti-Inflammatory Effects of Hesperidin in an Ex Vivo Mouse Model of Early-Onset Liver FibrosisInternational Journal of Molecular SciencesJanuary 7, 2026Ilenia Saponara, Miriam Cofano, Valentina De Nunzio, Giusy Bianco, Raffaele Armentano, Giuliano Pinto, Emanuela Aloisio Caruso, Matteo Centonze, Maria Notarnicolafibrotic-inducing experiments the slices were incubated with the pro-fibrotic compound TGF-β (cod. HY-P70543 MedChemExpress, Monmouth Junction, NJ, USA) for 48 h. To establish the effect of HE, the PCLSs were

(8) PARP1 stabilizes FOXN3 to suppress pulmonary fibrosis through p38-related feedback regulationSci AdvJanuary 2, 2026Xinxing Zhu, Qingyang Huo, Lele Jin, Jiang Du, Jinjin Yu, Huanhuan Wang, Nan Wu, Yingke Li, Yan Rui, Chengling Zhao, et al.used: BYK204165 (no. HY-108632, MedChemExpress), PJ34 (no. HY-13688A, MedChemExpress), and TGF-β (no. HY-P70543, MedChemExpress). The PARP1 protein purified from Sf9 insect cells was obtained from MedChemExpress

(9) Cancer immunology data engine reveals secreted AOAH as a potential immunotherapyCellSeptember 4, 2025Lanqi Gong, Jie Luo, Emily Yang, Beibei Ru, Ziyang Qi, Yuma Yang, Anshu Rani, Abhilasha Purohit, Yu Zhang, Grace Guan, et al.Biologics,WBP71306_1 Recombinant human IL-2 Protein,R&D Systems,202-IL "TGF beta 1/TGFB1 Protein, Human",MedChemExpress,HY-P70543 Human gp100 peptide (25–33),GenScript,RP20344 Mouse gp100 peptide (25–33),AnaSpec,AS-64752 OVA-N4

(10) Celastrol Activates SIRT1/PGC-1α/Nrf2 Axis to Inhibit Oxidative Damage for Subconjunctival Fibrosis AlleviationInvestigative Ophthalmology & Visual ScienceAugust 28, 2025Zhihua Guo, Huayang Feng, Xue Sun, Liu Yang, Qingyun Ning, Yuting Deng, Zhanrong Li, Jingguo Li(Shanghai, China). EX527 (CAS number 49843-98-3, cat. no. HY-15452) and Recombinant human TGF-β1 (cat no. HY-P70543) were obtained from MedChemExpress (Monmouth Junction, NJ, USA). The 2′,7′-dichlorofluorescein diacetate

(11) GPX3 promotes cisplatin resistance in TNBC by manipulating ROS-TGFB1-ZEB2Cell communication and signaling : CCSJuly 25, 2025Hu Q, Chen Q, Yang W, Ren A, Tan J, Huang T.receptor kinase inhibitors, TRKI, HY-10431), and recombinant human TGFβ1 protein from HEK293 (Cat. No. HY-P70543) were purchased from MedChemExpress (MCE). NAC (Cat. No. S0077) was purchased from Beyotime. ROS fluorescent

(12) Hesperidin Is a Promising Nutraceutical Compound in Counteracting the Progression of NAFLD In VitroInternational Journal of Molecular SciencesJune 21, 2025Miriam Cofano, Ilenia Saponara, Valentina De Nunzio, Giuliano Pinto, Emanuela Aloisio Caruso, Matteo Centonze, Maria Notarnicola44391 Sigma-Aldrich, St. Louis, MO, USA), and 3 ng/mL Transforming Growth Factor-Beta (TGF-β, cod. HY-P70543 MedChemExpress, Monmouth Junction, NJ, USA). OA and PA were prepared as stock solutions at 120 mM and

(13) The CD163 + tissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathwayJ Transl MedApril 10, 2025Xuemei Li, Siyi Wang, Hanwen Cao, Simin Xu, Chao Xiong, Jinhai Yu, Yunxiu Chen, Zhangjun Ren, Min Li, Ying Hu, et al.co-culture, RT-PCR and Western blot experiments were performed. Subsequently, the effect of TGF-β1 (HY-P70543, MedChemExpress, China) on OFs was explored. Cells were cultured in complete medium containing 5 ng/mL

(14) Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signalingNat CommunFebruary 21, 2025Jinjin Yu, Yingke Li, Yiming Li, Xiaotian Liu, Qingyang Huo, Nan Wu, Yangxia Zhang, Taoling Zeng, Yong Zhang, Henry You Li, et al.reagents were used: Cycloheximide (HY-12320, MedChemExpress), MG132 (HY-13259, MedChemExpress), and TGF-β (HY-P70543, MedChemExpress). Plasmid constructions Flag- or HA-tagged FOXN3, NEK6, and hnRNPU were constructed

(15) Anti-Inflammatory and Anti-Fibrotic Effects of a Mixture of Polyphenols Extracted from "Navelina" Orange in Human Hepa-RG and LX-2 Cells Mediated by Cannabinoid Receptor 2Int J Mol SciJanuary 9, 2025Ilenia Saponara, Emanuela Aloisio Caruso, Miriam Cofano, Valentina De Nunzio, Giuliano Pinto, Matteo Centonze, Maria Notarnicolamicrocentrifuge tubes for Western blot analysis. For TGF-β (TGF beta 1/TGFB1 Protein, Human (HEK293), Cat. No.: HY-P70543, MedChemExpress, Monmouth Junction, NJ, USA), a 100 µg/mL stock solution was prepared by dissolving

(16) Epigenetic modification regulates the ligamentum flavum hypertrophy through miR-335-3p/SERPINE2/β-catenin signaling pathwayCell Mol Biol LettJanuary 3, 2025Yongzhao Zhao, Shuai Jiang, Longting Chen, Qian Xiang, Jialiang Lin, Weishi Lifor subsequent cell experiments. To induce the fibrosis of LF cells, the recombinant protein TGF-β1 (#HY-P70543, MedChemExpress, USA) (10 ng/ml) was used to treat the LF cells. To inhibit the β-catenin signaling

(17) Efficacy and Mechanism of Alprostadil in Diabetes Mellitus Combined with Peripheral AtherosclerosisAnatolian journal of cardiologySeptember 18, 2024Yin H, Wan Q.specific primary antibodies GAPDH (Abcam; ab37168), transforming growth factor-β1 (TGF-β1; MedChemExpress; HY-P70543), Smad3 (Abcam; ab40854), p-Smad3 (Cell Signaling; 9520S), Smad7 (Proteintech; 66478-1-IG), and cleaved

(18) Phosphodiesterase type 5 inhibitor tadalafil reduces prostatic fibrosis via MiR-3126-3p/FGF9 axis in benign prostatic hyperplasiaBiology DirectAugust 2, 2024Tiewen Li, Yu Zhang, Zeng Zhou, Lvxin Guan, Yichen Zhang, Zhiyuan Zhou, Wenhao Wang, Xuehao Zhou, Di Cui, Chenyi Jiang, et al.tadalafil (HY-90,009 A), hydrocortisone (HY-N0583), insulin (Cat# HY-P73243), human recombinant TGFβ1 (HY-P70543), and human basic fibroblast growth factor (HY-P7331A) were purchased from MedChemExpress (NJ, USA).

(19) Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 PhosphorylationNeurochemical researchMay 1, 2024Li X, Yang Q, Jiang P, Wen J, Chen Y, Huang J, Tian M, Ren J, Yang Q.Methods Reagents 4,5,6,7-Tetrabromobenzotriazole (TBB) (HY-14394), transforming growth factor-β1 (TGF-β1) (HY-P70543) and SB431542 (HY-10431) were obtained from MedChemExpress (USA). Dimethyl sulfoxide (DMSO; D2650) was

(20) FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradationCell Death & DiseaseApril 13, 2024Ya Li, Caojian Zuo, Xiaoyu Wu, Yu Ding, Yong Wei, Songwen Chen, Xiaofeng Lu, Juan Xu, Shaowen Liu, Genqing Zhou, et al.(HY-13991), Bafilomycin A1 (HY-100558), MG-132 (HY-13259), Cycloheximide (CHX, HY-12320), and TGFβ (HY-P70543) were purchased from MCE. Rat model of MI Six-week-old male Sprague–Dawley rats (weight 200–250 g)

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TGF beta 1/TGFB1 Protein, Human (HEK293) from MedChemExpress

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TGF beta 1/TGFB1 Protein, Human (HEK293) from MedChemExpress

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