Z-IETD-FMK HY-101297 from MedChemExpress

Product Specs
ItemZ-IETD-FMK
CompanyMedChemExpress
Price $168.00Supplier Page View Company Product Page
Catalog NumberHY-101297
TypeChemical
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Size1 mg
Purity≥98.0%
Research AreaCancer

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(1) Boron neutron capture therapy preserves immune cells and induces robust anti-tumour immunity in preclinical mouse modelNature CommunicationsJanuary 8, 2026Qi Sun, Yanping Zhao, Simiao Qiao, Kexuan Wang, Chuanjie Lu, Zizhu Zhang, Zhibin Guo, Zexuan Ding, Chunhong Wang, Jiyuan Li, et al.HY-14622A, MCE), GSK872 (5 µM, HY-101872, MCE), Z-VAD-FMK (40 µM, HY-16658B, MCE), Z-IETD-FMK (25 µM, HY101297, MCE), ZDEVD-FMK (50 µM, HY-12466, MCE), and Ferrostatin-1 (5 µM, HY-100579, MCE). The cells were subsequently

(2) Probiotic-inspired hybrid nanovesicles for enhancing immune checkpoint therapy efficiency via tumor immune microenvironment modulationBioact MaterOctober 17, 2025Fang Wang, Jinghao Fan, Wenping Pan, Mingkang Liu, Jiaxin Wang, Xue Wei, Yiwen Xian, Shiyi Chen, Chunhong Cui, Yongmiao Chen, et al.activity of ROMV/TMAO in vivo, we procured a specific GzmB functional inhibitor (Z-IETD-FMK, MCE # HY-101297) alongside anti-IFN-γ neutralizing antibody (BioXcell #BE0055-5 MG) to block these key effectors during

(3) Rickettsia heilongjiangensis suppresses RIPK1 kinase-mediated host cell death during the infectionInfection and ImmunityAugust 12, 2025Maozhang He, Qingyin Shi, Yu Xin, Shurui Zheng, Yan Liu, Kehan Xu(HY12466) and used at a working concentration of 50 µM. Z-IETD-FMK, a caspase-8 inhibitor (MedChemExpress, HY-101297), was used with a working concentration of 30 µM. Necrostain-1, a RIPK1 inhibitor (MedChemExpress HY-15760),

(4) Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axisCell Death DisJune 17, 2025Gaoyan Tang, Xuelei Cao, Jiaqi Chen, Fu Hui, Na Xu, Yiqing Jiang, Hongmin Lu, Haifeng Xiao, Xiuming Liang, Mingzhe Ma, et al.Target Mol (Boston, USA). RG7388 (HY-15676), Nutlin-3a (HY-10029), Z-VAD-FMK (HY-16658B), Z-IETD-FMK (HY-101297), Z-DEVD-FMK (HY-12466), SM-164 (HY-15989), SP600125 (HY-12041), Hexadimethrine bromide (HY-112735)

(5) Apoptotic Caspases Suppress Expression of Endogenous Retroviruses in HPV31+ Cells That Are Associated with Activation of an Innate Immune ResponseVirusesOctober 30, 2024Caleb Studstill, Ning Huang, Shelby Sundstrom, Samantha Moscoso, Huirong Zhang, Blossom Damania, Cary Moodybovine growth serum. The pancaspase inhibitor IDN-6556 (#HY-10396), caspase-8 inhibitor (Z-IETD-FMK) (#HY-101297), and caspase-3 inhibitor (Z-DEVD-FMK) (#HY-12466) were purchased from MedChemExpress (Monmouth Junction,

(6) Strong activation of p53 by actinomycin D and nutlin-3a overcomes the resistance of cancer cells to the pro-apoptotic activity of the FAS ligandApoptosisOctober 1, 2024Barbara Łasut-Szyszka, Agnieszka Gdowicz-Kłosok, Małgorzata Krześniak, Magdalena Głowala-Kosińska, Agnieszka Będzińska, Marek Rusin(10 mM), Z-VAD-FMK (2 mM, cat. no. HY-16658B, pan caspase inhibitor) and Z-IETD-FMK (2 mM, cat no. HY-101297, caspase-8 inhibitor; MedChemExpress LLC, Monmouth Junction, NJ, USA). The stock solution of etoposide

(7) Jolkinolide B Inhibits Gastric Cancer Growth by Targeting the PANoptosis Molecular Switch Caspase-8Journal of CancerSeptember 30, 2024Chenhui Ma, Lei Gao, Kewei Song, Baohong Gu, Bofang Wang, Weigao Pu, Hao Chenatmosphere. Furthermore, the caspase-8 inhibitor Z-IETD-FMK was obtained from MedChemExpress (MCE, HY-101297). CCK-8 assays Following digestion, the cell suspension was diluted, and approximately 7,000 cells

(8) Influenza A virus infection activates caspase-8 to enhance innate antiviral immunity by cleaving CYLD and blocking TAK1 and RIG-I deubiquitinationCellular and molecular life sciences : CMLSAugust 19, 2024Yu H, Sun Y, Zhang J, Zhang W, Liu W, Liu P, Liu K, Sun J, Liang H, Zhang P, et al.suppresses antiviral responses. Materials and methods Reagents Z-VAD (OMe)-FMK (HY-16658), Z-IETD (HY-101297), and Z-DEVD (HY-12466) were purchased from MedChemExpress (MCE) LLC (Shanghai, China). 4,6-Diamidino-2-phenylindole

(9) c-FLIP facilitates ZIKV infection by mediating caspase-8/3-dependent apoptosisPLoS pathogensJuly 1, 2024Zhang S, Li N, Wu S, Xie T, Chen Q, Wu J, Zeng S, Zhu L, Bai S, Zha H, et al.Bone marrow-derived macrophages were isolated using a previously described method [12]. Inhibitor Z-IETD-FMK (MCE, HY-101297) and Ac-DEVD-CMK TFA (MCE, HY-P0034A) were purchased from MedChemExpress. IFN-α (Abclonal, RP01725)

(10) Human cytomegalovirus UL36 inhibits IRF3-dependent immune signaling to counterbalance its immunoenhancement as apoptotic inhibitorScience advancesOctober 6, 2023Ren Y, Wang A, Zhang B, Ji W, Zhu XX, Lou J, Huang M, Qiu Y, Zhou X.DNA sequencing. Cells were seeded onto the dish 24 hours before z-VAD-FMK, z-IETD-FMK, or z-LEHD-FMK (MCE, HY-16658B, HY-101297, and HY-P1010) treatment or transfection, and plasmids were transiently transfected by using Lipofectamine

(11) Cigarette Smoke Extract Induces p38 MAPK-Initiated, Fas-Mediated EryptosisInternational journal of molecular sciencesNovember 25, 2022Restivo I, Attanzio A, Giardina IC, Di Gaudio F, Tesoriere L, Allegra M.D1692) (15 μM), caspase-8 inhibitor Z-IETD-FMK (MedChemExpress, Monmouth Junction, NJ, USA, Cat. No. HY-101297) (25 μM) or p38 MAPK inhibitor SB203580 (MedChemExpress, Cat. No. HY-10256) (10 μM). Inhibitors were

(12) Mycoplasma ovipneumoniae induces caspase-8-dependent extrinsic apoptosis and p53- and ROS-dependent intrinsic apoptosis in murine alveolar macrophagesVirulenceDecember 1, 2021Chen J, Zhou Y, Zhu E, Yang P, Li M, Zhang S, Yue J, Wen M, Wang K, Cheng Z.N-acetyl-L-cysteine (NAC, HR8848) was obtained from Beijing Biolab. Caspase-8 inhibitor Z-IETD-FMK (HY-101297) was obtained from MedChemExpress. Rabbit anti-p53 (acetyl K370) antibody (ab183544) was purchased from

(13) Ddb1 Is Essential for the Expansion of CD4⁺ Helper T Cells by Regulating Cell Cycle Progression and Cell DeathFrontiers in immunologyJanuary 1, 2021Yang L, Chen W, Li L, Xiao Y, Fan S, Zhang Q, Xia T, Li M, Hong Y, Zhao T, et al.treated with various inhibitors in CD4+ T-cell stimulation assay. Z-VAD (cat #HY-16658B), Z-IETD (cat #HY-101297), Ferrostatin-1 (cat # HY-100579), GSK872 (cat #HY-101872), Nec1 (cat # HY-15760), AZD7762 (cat # HY-10992),

(14) Exosome-Derived LncRNA TCONS_00072128 Mediated Osteogenic Differentiation and Inflammation by Caspase 8 RegulationFrontiers in geneticsJanuary 1, 2021Yang Y, Miao L, Chang S, Zhang Q, Yu L, He P, Zhang Y, Fan W, Liu J, Hao X.for 3–5 times, cells were treated with lentivirus infection or 5 μM caspase 8 inhibitor Z-IETD-FMK (HY-101297, MCE) for 1 day or 7 days before subsequent experiments. This study was approved by the Seventh Medical

(15) Quercetin Induces Apoptosis via Downregulation of Vascular Endothelial Growth Factor/Akt Signaling Pathway in Acute Myeloid Leukemia CellsFrontiers in pharmacologyJanuary 1, 2020Shi H, Li XY, Chen Y, Zhang X, Wu Y, Wang ZX, Chen PH, Dai HQ, Feng J, Chatterjee S, et al.Selleck (St. Houston, TEX), dimethyl sulfoxide (DMSO) was purchased from MP Biomedicals. Z-IETD-FMK (HY-101297) and Z-VAD-FMK (HY-16658B) were purchased from MCE, Z-LEHD-FMK (B3233) was provided by APEXBIO. Human

(16) Granzyme B Is an Essential Mediator in CD8(+) T Cell Killing of Theileria parva-Infected CellsInfection and immunityJanuary 1, 2019Yang J, Pemberton A, Morrison WI, Connelley T.

(17) Pharmacological inhibition of caspase-8 limits lung tumour outgrowthBritish journal of pharmacologyAugust 1, 2015Terlizzi M, Di Crescenzo VG, Perillo G, Galderisi A, Pinto A, Sorrentino R.

(18) Outcome of acute myeloid leukemia and high-risk myelodysplastic syndrome according to health insurance statusClinical lymphoma, myeloma & leukemiaDecember 1, 2014Al-Ameri A, Anand A, Abdelfatah M, Kanaan Z, Hammonds T, Haller N, Cherry M.

(19) Suppression of human T cell proliferation by the caspase inhibitors, z-VAD-FMK and z-IETD-FMK is independent of their caspase inhibition propertiesToxicology and applied pharmacologyNovember 15, 2012Lawrence CP, Chow SC.

(20) z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen speciesBloodApril 1, 2005Cowburn AS, White JF, Deighton J, Walmsley SR, Chilvers ER.

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Z-IETD-FMK from MedChemExpress

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Z-IETD-FMK from MedChemExpress

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