Deoxyribonuclease I LS002009 from Worthington Biochemical Corporation

Product Specs
ItemDeoxyribonuclease I
CompanyWorthington Biochemical Corporation
Price Supplier Page View Company Product Page
Catalog NumberLS002009
Source/Expression SystemBovine Pancreas
StorageStore at 2-8C. PROTECT FROM MOISTURE
Activity≥2,000 Kunitz units per mg dry weight
SizeBulk

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Worthington Biochemical Corporation

Lakewood, New Jersey 8701

United States

Phone: 1.800.445.9603
1.732.942.1660

Email: custservice@worthington-biochem.com

Company Profile

Website: worthington-biochem.com

(1) Environmental cues signal through circadian control of sarcomeric gene expression during cardiomyocyte hypertrophyEpigeneticsJuly 22, 2026Adrian Arrieta, Alexa Jennings, Pratiti Dasgupta, Natalie D. Gehred, Tatiana Gromova, Erik Sandoval, Kunhua Song, Mansoureh Eghbali, Matthew A. Fischer, Thomas M. Vondriska0.1% Trypsin (Sigma-Aldrich, Cat. No. T4799) and 0.002% DNase (Worthington Biochemical Corp, Cat. No. LS002006). Each digestion lasted for 10 to 20 min. The cell suspension from the first digestion was discarded

(2) An ITGA11 expressing subpopulation as predictor for the donor-specific osteogenic capacity of stromal cellsBone ResJune 15, 2026Ali Jasim Mohammad Jamil, Kaja Madsen, Souad Daamouch, Birgitte Villadsen, Chao Ma, Shakespeare Jeromdesella, Mikkel Ørnfeldt Nørgård, Emilie Grupe, Maria Bruun Jakobsson, Yuting Wang, et al.digestion buffer containing 3 mg/mL type II collagenase (C6885, Sigma-Aldrich) and 100 U/mL DNase I (LS002007, Worthington Biochemical Corporation). After 40-min digestion at 37 °C, cells were filtered through

(3) Mice on a high-fat diet have reduced immunopathology and an altered immune response during respiratory syncytial virus infectionmBioJune 10, 2026Kendall T. Whitt, Dorothea R. Morris, Pamela H. Brigleb, Lauren Rowland, Heather Sheppard, Stacey Schultz-CherryU/mL Collagenase IV (Worthington Biochemical, LS004189) and 60 U/mL DNase I (Worthington Biochemical, LS002007) in 1.5 mL of RPMI for 30 min at 37°C on a shaker. Samples were passed through a 100 µm strainer to

(4) 3’UTR regulation of axon translation and optic nerve regenerationMolecular NeurodegenerationMay 29, 2026Minjuan Bian, Emma L. Huie, Xin Xia, Michael Nahmou, Savana A. Maxfield, Liang Li, Liang Liu, Ziming Luo, Christina Tsien, Katherine J. Healzer, et al.at 37 °C. The dissociated tissue was then pelleted and treated with DNase (Worthington Biochemical, LS002006) in HBSS with calcium and magnesium. After two washes and spin centrifugations, neurons were dissociated

(5) Astrocytes connect specific brain regions through plastic networksNatureApril 22, 2026Melissa L. Cooper, Maria Clara Selles, Michael Cammer, Chase Redd, Holly K. Gildea, Joseph Sall, Katelyn E. Chiurri, Philip Cheung, Damian G. Wheeler, Aiman S. Saab, et al.Dulbecco’s PBS (VWR, SH30264.FS) with BSA (BSA, Sigma-Aldrich, A4161) and DNase (Worthington Biochemical, LS002007), and filtered using a 20 µm nitex filter. The suspension was negatively panned for non-specific secondary

(6) Astrocyte-microglia crosstalk through Hevin and Toll-like receptor signaling controls developmental thalamocortical synapse refinementNeuronApril 15, 2026Juan J. Ramirez, Evelyn J. Hardin, Kristina Sakers, Jinhu Kim, Crystal Colón Colón Ortiz, Justin T. Savage, Richa Hanamsagar, Carina L. Block, Sandeep K. Singh, Staci D. Bilbo, et al.,Thermo Fisher,Cat# 11960069 Papain,Worthington Biochemical,Cat# LK003178 Dnase,Worthington Biochemical,Cat# LS002007 EBSS,Thermo Fisher,Cat# 14155063 Celltrics 30 um filter,Sysmex,Cat# 04-004-2326 Triton X-100,Roche,Cat#

(7) Microbiota-derived secondary bile acids promote STING activation and antitumor activitybioRxivApril 12, 2026Xinglin Yang, Xing Zhang, Weichao Li, Anant Gharpure, Althea Hansel-Harris, Andreas F. Tillack, Chongyang Wu, Yan-Zhu Hsieh, Ariana Sulpizio, Kyong T. Fam, et al.RPMI containing 1.5 U/mL Liberase TM (Roche, 5401119001), 0.2 mg/mL DNase I (Worthington Biochemical, LS002006), and ceramic spheres (6.35 mm, MP Biomedicals, 116540424-CF). The tissue was incubated at 37 °C with

(8) A Cisplatin-Based Prodrug Inhibits Nucleotide Excision Repair Independently of Chromatin Accessibility to Overcome ResistanceBiomoleculesApril 7, 2026Ya’ara Negev-Korem, Hadar Golan-Berman, Elisheva Heilbrun, Subhendu Karmakar, Yoram Soroka, Marina Frušić-Zlotkin, Ofer Chen, Hiba Hassanain, Esther Stern, Ori Wald, et al.Prior to beginning the ATAC-seq protocol, drug-containing media was replaced with 200 units/mL DNase (LS002006, Worthington Biochemical Corp, Lakewood, NJ, USA) in 1.2 mM MgCl2 and 0.5 mM CaCl2 for 30 min. ATAC-seq

(9) Myofibroblast programming blocks differentiation of TLS-organizing fibroblastic reticular cells in pancreatic cancerCancer CellMarch 26, 2026Elijah Kirschstein, Olivia Harder, Jordan Krull, Madison Sikorski, Shrijan Khanal, Morgan Mack, Carl F. Ware, Elizabeth Evans, Michael J. Gough, Qin Ma, et al.#328420250 "Collagenase, Type IV",Worthington Biochemical,Cat#LS004186 DNase I,Worthington Biochemical,Cat #LS002004 Bovine serum albumin (BSA),Sigma-Aldrich,Cat #A9418 EDTA,Thermo Fisher Scientific,Cat #AM9261 Trypsin-EDTA

(10) Epigenetic memory of colitis promotes tumour growthNatureMarch 25, 2026Surya Nagaraja, Lety Ojeda-Miron, Ruochi Zhang, Ena Oreskovic, Conrad Hock, Yan Hu, Daniel Zeve, Karina Sharma, Roni R. Hyman, Qiming Zhang, et al.(Millipore, C9263-25MG), 1.25 U ml−1 dispase (Millipore, D4693-1G), 1 U ml−1 DNase (Worthington Biochemical, LS002004) and 5 μM Y-27632 (R&D, 1254). Cells were washed with 0.1% BSA/PBS, stained with Calcein Red-AM (BioLegend,

(11) Pain Outcome Determines the Sensitivity to Peripheral Opioid Antagonism of Morphine, Ibuprofen, and Their Combination in Laparotomized MicePharmaceuticsMarch 21, 2026Makeya A. Hasoun, Miriam Santos-Caballero, Miguel Á. Huerta, María Robles-Funes, Amada Puerto-Moya, M. Carmen Ruiz-Cantero, Enrique J. Cobos, Rafael González-Canosolution containing 1 mg/mL collagenase IV (LS004188, Worthington, Lakewood, NJ, USA) and 0.1% DNase I (LS002007, Worthington Biochemical Corporation, Lakewood, NJ, USA). This digestion proceeded under continuous

(12) Human neuromodulatory assembloids to study serotonin signaling and diseasebioRxivMarch 13, 2026Sabina Kanton, Xiangling Meng, Chunyang Dong, Fikri Birey, Dong Wang, Noah Reis, Se-Jin Yoon, Ji-Il Kim, James P. McQueen, Noriaki Sakai, et al.ethylenediaminetetraacetic acid (EDTA), 26 mM NaHCO3, 125 U ml−1 Deoxyribonuclease I (Worthington Biochemical, LS002007) and 6.1 mM L-cysteine (Sigma-Aldrich, C7880)) for 45 mins at 37°C with swirling in between. Then, organoids

(13) Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibilityCellMarch 10, 2026Jérémie Rispal, Jasmine R. Garcia, Brisa Palikuqi, Manasa Vegesna, Dedeepya Vaka, Seung Woo Kang, Coralie Trentesaux, Juan Du, Nicola R. Realini, Paige N. Spencer, et al.acid,Invitrogen,Cat# 15575020 Dispase II,Millipore Sigma,Cat# D4693 DNase I,Worthington Biochemical,Cat# LS002007 Tamoxifen,Millipore Sigma,Cat# T5648-5G Corn Oil,Millipore Sigma,Cat# C8267 Paraformaldehyde,Fischer

(14) Co-Delivery of Synaptogenic and Angiogenic Nanoparticles in MAP Scaffolds Enhances Post-Stroke Synapse FormationJournal of Materials Chemistry BFebruary 25, 2026Nhi Van Phan, Jeremy Lee Thomas, Aiden Pasinsky, Zoe Meadows, Ting Ting Li, Augustus Adams, Yike Zhu, Anna Edgcomb, Yi Shi, Sihan Lyu, et al.Trypsin/EDTA (Gibco, Cat. No. 25200056) with 500 µL of 40 000 U mL−1 DNase (Worthington Biochemical, Cat. No. LS002006) that had been equilibrated in a CO2 incubator for a minimum of 30 minutes beforehand. Cortices were

(15) Use of a human immortalized microglia cell line to study recognition, phagocytosis, and intracellular survival of Cryptococcus neoformansmSphereFebruary 24, 2026Robbi L. Ross, Kassandra Arias-Parbul, Zane M. Douglass, Katrina L. Adams, Felipe H. Santiago-Tirado[Worthington Biochemical LS003126] dissolved in EBSS [Invitrogen], 1× DNase I [Worthington Biochemical LS002007; 500× stock solution prepared by dissolving 12,500 U of DNase I in 1 mL of EBSS]) was added to the brain

(16) Peptide‐Induced Ferroelectricity in Charge‐Transfer Supramolecular MaterialsAdvanced MaterialsFebruary 1, 2026James V. Passarelli, Yang Yang, Cara S. Smith, Jing Hao, Dhwanit R. Dave, Ashwin Narayanan, Zaida Álvarez, Broderick K. Johnson, Kelly A. Marshall, Ivan Fithian, et al.(Gibco, Cat. No. 25200072) solution with 250 µL of 4000 U/mL DNAse I (Worthington Biochemical, Cat. No. LS002006). After 10 min, cortices were placed and then mechanically dissociated in 5 mL of pre‐plating media

(17) Interpretable inflammation landscape of circulating immune cellsNature MedicineFebruary 1, 2026Laura Jiménez-Gracia, Davide Maspero, Sergio Aguilar-Fernández, Francesco Craighero, Maria Boulougouri, Max Ruiz, Domenica Marchese, Ginevra Caratù, Jose Liñares-Blanco, Miren Berasategi, et al.incubated during 10 minutes at room temperature with 0.1 mg ml−1 DNAse I (Worthington Biochemical, PN LS002007) to eliminate ambient DNA and favor the resuspension of the pellet. Cells were filtered with a 40-µm

(18) Epigenomic, transcriptomic, and proteomic characterization of breast cancer cell line reference samplesCell Reports MethodsJanuary 26, 2026Chirag Nepal, Wanqiu Chen, Zhong Chen, John A. Wrobel, Ling Xie, Wenjing Liao, Chunlin Xiao, Adrew Farmer, Malcolm Moos, Wendell Jones, et al.peptides, and recombinant proteins" ,, Deoxyribonuclease I (DNase I),Worthington Biochemical Corporation,LS002007 MgCl2 solution,Sigma-Aldrich,68475 NaCl solution,Sigma-Aldrich,S5150 Nonidet P40 Substitute,Sigma-Aldrich,11332473001 Digitonin

(19) Erythrocyte-microglia crosstalk contributing to sex differences in pediatric brain tumorigenesisResearch SquareJanuary 20, 2026Baoli Hu(Worthington Biochemical Corporation, LS004209), 1 mg/ml Deoxyribonuclease I (Worthington Biochemical Corporation, LS002007) and 2 mg/ml soybean trypsin inhibitor (Worthington Biochemical Corporation, LS003587) in DPBS for 10

(20) The Recycling Collagen Receptor uPARAP Is a Unique Mediator of Stromal Drug Delivery to Carcinoma CellsMolecular cancer therapeuticsJanuary 2, 2026Nørregaard KS, Larsen IME, Jürgensen HJ, Blomquist MH, Çakilkaya P, Metrangolo V, Perlado AM, Krigslund O, Gårdsvoll H, Poulsen TT, et al.included collagenase type I (CAS no. 9001-12-1, cat. no. LS004197), DNAse I (CAS no. 9003-98-9, cat. no. LS002006, Worthington Biochemical), neutral protease (dispase, CAS no. 9001-92-7, cat. no. LS02100, Worthington Biochemical

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Deoxyribonuclease I from Worthington Biochemical Corporation

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Worthington Biochemical Corporation

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Deoxyribonuclease I from Worthington Biochemical Corporation

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