Description
A peptide inhibitor of NTMT1 (IC50 = 0.054 µM); binds to NTMT1 and NTMT2 (Kds = 0.3 and 1 µM, respectively) and inhibits N-terminal dimethylation of RCC1 by NTMT1 in a cell-free assay at 10 and 50 µM; reduces trimethylation of the RCC1 SPKRIA motif in HCT116 cells at 100 µM