Description
A peptide inhibitor of DRP1; selectively inhibits DRP1 GTPase activity over OPA1, MFN1, and dynamin 1 at 1 µM; inhibits the MPP+-induced protein-protein interaction between DRP1 and FIS1, as well as stress-induced DRP1 translocation to the mitochondria in SH-SY5Y cells; inhibits MPP+-induced mitochondrial apoptosis and autophagy in SH-SY5Y cells and MPP+-induced mitochondrial fragmentation and cell death in a primary rat dopaminergic neuronal model of Parkinson’s disease