Description
An autophagy-inducing peptide; binds to GAPR-1 in HeLa cells and induces conversion of LC3-I to LC3-II via lipidation and autophagosome formation in MCF-7 cells at 30 µM; decreases viral titers in HeLa cells infected with Sindbis virus, chikungunya, or West Nile virus at 10 µM; inhibits HIV p24 antigen release and viral replication in primary human MDMs from 0.5-5 µM; reduces intramuscular viral titers, neonatal mortality, and paralysis and increases muscle cell autophagosome formation in chikungunya-infected neonatal mice at 14 mg/kg