Description
Human GITR/TNFRSF18 Recombinant Protein Fc Tag Lyophilized has been recombinantly produced in HEK293 cells.
Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.
This protein carries a human IgG1 Fc Tag at the C-terminal. The protein has a calculated MW of 41.0 kDa. The protein migrates as 45-47 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation