Description
The protein encoded by IL8 gene is a member of the CXC chemokine family and is a major mediator of inflammatory responses. The IL-8 protein is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis (a common respiratory tract disease caused by the respiratory syncytial virus (RSV), the lung inflammation associated with csytic fibrosis, coronary artery disease and endothelial dysfunction. IL-8 is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q