Description
FGF-2, also known as basic fibroblast growth factor (bFGF), is an important member of fibroblast growth factor (FGF) family. FGF-2 is a cationic polypeptide with a molecular weight of 16 ~ 18000 and an isoelectric point of 9.6. FGF2 can be produced by vascular endothelial cells, retinal pigment epithelial cells, photoreceptor cells, m ü ller cells and astrocytes. It widely exists in a variety of tissues in vivo and mainly plays a role through autocrine and paracrine. The signal pathway induced by FGF2 is necessary for normal cell growth and differentiation. It exists in almost all cells. FGF2 binds to FGFR, which makes the receptor dimerize and tyrosine kinase is activated, triggering a series of intracellular phosphorylation cascade reactions to regulate cell growth Differentiation and apoptosis. Under normal conditions, FGF-2 binds to heparin and does not produce biological effects. However, in some pathological cases, the integrity of cells is destroyed, which can release the stored form of FGF-2, promote angiogenesis and participate in the process of tissue repair. FGF-2 and FGFR are almost distributed in various tissues of the whole body. FGF-2 is the strongest known cytokine. It plays an important role in promoting angiogenesis, wound healing, tissue injury repair, neuroprotection, embryonic development and tumor formation. FGF-2 has two main functions, inducing endothelial cell germination and proliferation and increasing vascular permeability. In addition, studies have shown that FGF2 is also closely related to depression