Description
Podocalyxin, also known as PODXL, is a member of the CD34 sialomucin protein family. It is present in glomerular podocytes, endothelial cells, glandular cells in fallopian tube, uterus. A soluble form of Podocalyxin can be released into the urine of women with pre-eclampsia. It has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2. And Its interactions with L-Selectin and E-Selectin mediate the tethering of lymphocytes and metastatic tumor cells to the vascular endothelium. It is upregulated in a number of cancers and is frequently associated with poor prognosis. Based on patient survival data, high level of PODXL transcripts in tumor cells is associated with poor prognosis in renal cancer. Recombinant human Podocalyxin, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques