Description
CD140 b Recombinant Protein His Tag Lyophilized has been recombinantly produced in HEK293 cells.
Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) is also called J03278, M21616, CD140B, JTK12, PDGF-R-beta and PDGFR, is receptor that binds specifically to PDGFB and has a tyrosine-protein kinase activity. Is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor (PDGF) family. The PDGFR/PDGF system includes two receptors (PDGFRA and PDGFRB) and four ligands (A, B, C and D). The receptors PDGFRA and PDGFRB are related in sequence and both are members of the class III subtype of receptor tyrosine kinases (RTKs). Other class III RTKs are CSF1R, KIT and FLT3. PDGF binding induces receptor homo- and heterodimerization and signal transduction. The expression of the alpha and beta receptors is independently regulated in various cell types. Recombinant soluble PDGFRB binds PDGF with high affinity and is potent PDGF anTagonist. The ligands form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-alpha and -beta. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -alphaalpha, -betabeta and -alphabeta. PDGF-CC specifically interacts with PDGFR-alphaalpha and -alphabeta, but not with -betabeta, and thereby resembles PDGF-AB. PDGF-DD binds to PDGFR-betabeta with high affinity, and to PDGFR-alphabeta to a much lower extent and is regarded as PDGFR-betabeta specific. PDGF-AA binds only to PDGFR-alphaalpha, while PDGF-BB is the only PDGF that can bind all three receptor combinations with high affinity.
This recombinant protein can be used for WB