Description
YES1 (YES Proto-Oncogene 1, Src Family Tyrosine Kinase), a non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, YES1 promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly and participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, YES1 phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration and participates in CD95L/FASLG signaling pathway and mediates AKTmediated cell migration. YES1 plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase