Description
B7-H6, also known as NCR3LG1, is a member of the B7 family of immune co?stimulatory proteins. B7-H6 is as a cell-surface ligand for the NKp30-activating receptor expressed on natural killer cells. It is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, and is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30?dependent cell lysis. Recombinant human B7-H6, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques